2 documents found, page 1 of 1
A conformational switch controlling the toxicity of the prion protein
Frontzek, K; Bardelli, M; Senatore, A; Henzi, A; Reimann, RR; Bedir, S; Marino, M; Hussain, R; Jurt, S; Meisl, G; Pedotti, M; Mazzola, F; Siligardi, GPrion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond (‘H-latch’), altering the flexibility of the α2–α3 and β2–α2 loops of PrPC. Expression of a PrP2Cys mutant mimicking the H-latch was constitutively toxic, whereas a PrPR207A mutant unabl...
Hepatic wnt1 inducible signaling pathway protein 1 (WISP-1/CCN4) associates wit...
Pivovarova-Ramich, O; Loske, J; Hornemann, S; Markova, M; Seebeck, N; Rosenthal, A; Klauschen, F; Castro, JP; Buschow, R; Grune, T; Lange, VLiver fibrosis is a critical complication of obesity-induced fatty liver disease. Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4), a novel adipokine associated with visceral obesity and insulin resistance, also contributes to lung and kidney fibrosis. The aim of the present study was to investigate the role of CCN4 in liver fibrosis in severe obesity. For this, human liver biopsies were collected from 3...