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Cryogenic, but not hypothermic, preservation disrupts the extracellular matrix ...

Ribeiro, Sara Cristina Freitas; Carvalho, A. F.; Rodrigues, Daniel Barreira; Martins, L.; Pires, R. A.; Mendes, V. M.; Manadas, B.; Jarnalo, M.

Cell sheet (CS)-based approaches hold significant potential for tissue regeneration, relying on the extracellular matrix (ECM) for success. Like in native tissues, the ECM provides structural and biochemical support for cellular homeostasis and function. Effective preservation strategies that maintain ECM integrity are critical to enhance the therapeutic potential of CS-based approaches. While cryogenic and hyp...


Prevascularized spongy-like hydrogels maintain their angiogenic potential after...

Ribeiro, Sara Cristina Freitas; Moreira, H.; da Silva, Lucília Pereira; Noro, Jennifer Martins; Sampaio-Marques, B.; Ludovico, Paula; Jarnalo, M.

The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization being a critical factor for in vivo survival and integration of tissue engineering products. Concurrently, a different challenge hindering the clinical impleme...


PVM-based intelligent predictive control of HVAC systems

Ruano, Antonio; Pesteh, S.; Silva, S.; Duarte, H.; Mestre, G.; Ferreira, P. M.; Khosravani, Hamid Reza; Horta, R.

This paper describes the application of a complete MBPC solution for existing HVAC systems, with a focus on the implementation of the objective function employed. Real-time results obtained with this solution, in terms of economical savings and thermal comfort, are compared with standard, temperature regulated control.(1) (C) 2016, IFAC (International Federation of Antomatic Control) Hosting by Elsevier Ltd. Al...


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