14 documents found, page 1 of 2
Psychiatric neuroimaging research in Brazil: historical overview, current chall...
Busatto Filho,Geraldo; Rosa,Pedro G.; Serpa,Mauricio H.; Squarzoni,Paula; Duran,Fabio L.The last four decades have witnessed tremendous growth in research studies applying neuroimaging methods to evaluate pathophysiological and treatment aspects of psychiatric disorders around the world. This article provides a brief history of psychiatric neuroimaging research in Brazil, including quantitative information about the growth of this field in the country over the past 20 years. Also described are the...
Subjective sleep parameters in prodromal Alzheimer’s disease: a case-control study
Borges,Conrado R.; Piovezan,Ronaldo D.; Poyares,Dalva R.; Busatto Filho,Geraldo; Studart-Neto,Adalberto; Coutinho,Artur M.; Tufik,SergioObjective: People with Alzheimer’s disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and compared their amyloid profiles. Methods: We enrolled 30 participants aged ≥ 60 years, with no dementia or major clini...
Topography of 11C-Pittsburgh compound B uptake in Alzheimer’s disease: a voxel-...
Faria,Daniele de P.; Duran,Fabio L.; Squarzoni,Paula; Coutinho,Artur M.; Garcez,Alexandre T.; Santos,Pedro P.; Brucki,Sonia M.; de Oliveira,Maira O.Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer’s disease (AD), and explore possible group differences in 11C-PIB binding to white matter. Methods: 11C-PIB PET scans wer...
Voxel-based morphometry in Alzheimers disease and mild cognitive impairment: Sy...
Ribeiro,Luís Gustavo; Busatto Filho,GeraldoABSTRACT Voxel-based morphometry (VBM) is a useful approach for investigating neurostructural brain changes in dementia. We systematically reviewed VBM studies of Alzheimer's disease (AD) and mild cognitive impairment (MCI), specifically focusing on grey matter (GM) atrophy in the frontal lobe. Methods: Two searches were performed on the Pubmed database. A set of exclusion criteria was applied to ensure the sel...
Psychopathic traits in young offenders vs. non-offenders in similar socioeconom...
Castellana,Gustavo B.; Barros,Daniel M. de; Serafim,Antonio de P.; Busatto Filho,GeraldoObjective: To analyze the differences in psychopathic traits between offender and non-offender youths with similar socioeconomic backgrounds. Method: The Psychopathy Checklist Revised (PCL-R) scale was used to identify whether 39 young offenders with no history of mental disorders or criteria for psychopathy exhibited differences in its total score, and specifically for factor 1 or factor 2 of this scale, when ...
Depression and temporal lobe epilepsy represent an epiphenomenon sharing simila...
Valente,Kette D. R.; Busatto Filho,GeraldoThe relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy caused by mesial te...
New molecular targets for PET and SPECT imaging in neurodegenerative diseases
Benadiba,Marcel; Luurtsema,Gert; Wichert-Ana,Lauro; Buchpigel,Carlos Alberto; Busatto Filho,GeraldoThe pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired function or expression in AD, PD and other ND, such as amyloid beta (Aβ), α-synuclein, tau protein and neuroinflam...
BDNF gene polymorphism, cognition and symptom severity in a Brazilian populatio...
Martinho Jr,Eduardo; Michelon,Leandro; Ayres,Adriana M; Scazufca,Marcia; Menezes,Paulo R; Schaufelberger,Maristela S; Murray,Robin M; Rushe,Teresa M.OBJECTIVE: To investigate the influence of brain-derived neurotrophic factor (BDNF) gene variations on cognitive performance and clinical symptomatology in first-episode psychosis (FEP). METHODS: We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with s...
Cerebral perfusion and automated individual analysis using SPECT among an obses...
Rocha,Euclides Timóteo da; Buchpiguel,Carlos Alberto; Miguel,Euripedes Constantino; Peres,Stela Verzinhase; Busatto Filho,GeraldoOBJECTIVE: To make individual assessments using automated quantification methodology in order to screen for perfusion abnormalities in cerebral SPECT examinations among a sample of subjects with OCD. METHODS: Statistical parametric mapping (SPM) was used to compare 26 brain SPECT images from patients with OCD individually with an image bank of 32 normal subjects, using the statistical threshold of p < 0.05 (cor...
Efeitos cerebrais da maconha: resultados dos estudos de neuroimagem
Crippa,José Alexandre; Lacerda,Acioly L T; Amaro,Edson; Busatto Filho,Geraldo; Zuardi,Antonio Waldo; Bressan,Rodrigo AA maconha é a droga ilícita mais utilizada. Apesar disto, apenas um pequeno número de estudos investigaram as conseqüências neurotóxicas de longo prazo do uso de cannabis. As técnicas de neuroimagem se constituem em poderosos instrumentos para investigar alterações neuroanatômicas e neurofuncionais e suas correlações clínicas e neuropsicológicas. Uma revisão computadorizada da literatura foi conduzida nos index...