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Apoe variants in an iberian alzheimer cohort detected through an optimized sang...
González, RD; Gomes, I; Gomes, C; Rocha, R; Durães, L; Sousa, P; Figueruelo, M; Rodríguez, M; Pita, C; Hornero, R; Gómez, C; Lopes, AM; Pinto, NThe primary genetic risk factor for late onset Alzheimer’s disease (LOAD) is the APOE4 allele of Apolipoprotein E (APOE) gene. The three most common variants of APOE are determined by single nucleotide polymorphisms (SNPs) rs429358 and rs7412. Our aim was to estimate allele and genotype frequencies of APOE variants in an Iberian cohort, thus helping to understand differences in APOE-related LOAD risk observed a...
Date: 2021
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Origin: Repositório Aberto da Universidade do Porto