4 documents found, page 1 of 1
Differential production of type I IFN determines the reciprocal levels of IL-10...
Howes, Ashleigh; Taubert, Christina; Blankley, Simon; Spink, Natasha; Wu, Xuemei; Graham, Christine M.; Zhao, Jiawen; Saraiva, MargaridaPattern recognition receptors detect microbial products and induce cytokines, which shape the immunological response. IL-12, TNF-alpha, and IL-1 beta are proinflammatory cytokines, which are essential for resistance against infection, but when produced at high levels they may contribute to immunopathology. In contrast, IL-10 is an immunosuppressive cytokine, which dampens proinflammatory responses, but it can a...
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks r...
McNab, Finlay W.; Ewbank, John; Howes, Ashleigh; Teixeira, Lucia de Fatima Moreira; Martirosyan, Anna; Ghilardi, Nico; Saraiva, Margarida; O’Garra, AnneTuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes ~1.4 million deaths per year, and it therefore remains a leading global health problem. The immune response during tuberculosis remains incompletely understood, particularly regarding immune factors that are harmful rather than protective to the host. Overproduction of the type I IFN family of cytokines is associate...
Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activate...
Rodrigues, Fernando; Pedrosa, Jorge; Coelho, Maria Teixeira; Guedes, Joana; Ferreirinha, Pedro; Howes, Ashleigh; Lai, Wi S.; Blackshear, Perry J.The activation of TLRs by microbial molecules triggers intracellular-signaling cascades and the expression of cytokines such as IL-10. Il10 expression is tightly controlled to ensure effective immune responses, while preventing pathology. Maximal TLR-induction of Il10 transcription in macrophages requires signaling through the MAPKs, ERK, and p38. Signals via p38 downstream of TLR4 activation also regulate IL-1...
The regulation of IL-10 expression
Saraiva, Margarida; Gabryšová, Leona; Howes, Ashleigh; O’Garra, AnneInterleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T c...