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2-Aryladenine derivatives as a potent scaffold for adenosine receptor antagonis...

Areias, Filipe; Correia, Carla; Rocha, Ashly; Teixeira, Sofia; Castro, Marián; Brea, Jose; Hu, Huabin; Carlsson, Jens; Loza, Maria I.

A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A<inf>1</inf>, A<inf>2A</inf>, A<inf>2B</inf>, and A<inf>3</inf> adenosine receptor subtypes. Eleven purines showed potent antagonism at A<inf>1</inf>, A<inf>3</inf>, dual A<inf>1</inf>/A<inf>2A</inf>, A<inf>1</inf>/A<inf>2B</inf>, or A<inf>1</inf>/A<inf>3</inf> adenosine receptor...

Date: 2024   |   Origin: RepositóriUM - Universidade do Minho
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