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Global, regional, and national burden of mortality associated with cold spells ...

Gao, Y; Huang, W; Zhao, Q; Ryti, N; Armstrong, B; Gasparrini, A; Tong, S; Pascal, M; Urban, A; Zeka, A; Lavigne, E; Madureira, J; Goodman, P; Huber, V

BACKGROUND: Exposure to cold spells is associated with mortality. However, little is known about the global mortality burden of cold spells. METHODS: A three-stage meta-analytical method was used to estimate the global mortality burden associated with cold spells by means of a time series dataset of 1960 locations across 59 countries (or regions). First, we fitted the location-specific, cold spell-related morta...


Ambient fine particulate matter and daily mortality: a comparative analysis of ...

Yu, W; Huang, W; Gasparrini, A; Sera, F; Schneider, A; Breitner, S; Kyselý, J; Schwartz, J; Madureira, J; Gaio, V; Guo, YL; Xu, R; Chen, G; Yang, Z

Background: Model-estimated air pollution exposure products have been widely used in epidemiological studies to assess the health risks of particulate matter with diameters of ≤2.5 µm (PM2.5). However, few studies have assessed the disparities in health effects between model-estimated and station-observed PM2.5 exposures. Methods: We collected daily all-cause, respiratory and cardiovascular mortality data in 34...


Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Tempera...

Hundessa, S; Huang, W; Zhao, Q; Wu, Y; Wen, B; Alahmad, B; Armstrong, B; Gasparrini, A; Sera, F; Tong, S; Madureira, J; Kyselý, J; Schwartz, J

Background: The association between nonoptimal temperatures and cardiovascular mortality risk is recognized. However, a comprehensive global assessment of this burden is lacking. Objectives: The goal of this study was to assess global cardiovascular mortality burden attributable to nonoptimal temperatures and investigate spatiotemporal trends. Methods: Using daily cardiovascular deaths and temperature data from...


Mortality risks associated with floods in 761 communities worldwide: time serie...

Yang, Z; Huang, W; McKenzie, JE; Xu, R; Yu, P; Ye, T; Wen, B; Gasparrini, A; Armstrong, B; Tong, S; Lavigne, E; Madureira, J; Kyselý, J; Guo, Y; Li, S

Objective To evaluate lag-response associations and effect modifications of exposure to floods with risks of all cause, cardiovascular, and respiratory mortality on a global scale. Design Time series study. Setting 761 communities in 35 countries or territories with at least one flood event during the study period. Participants Multi-Country Multi-City Collaborative Research Network database, Australian Cause o...


Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Nogueira, RG; Qureshi, MM; Abdalkader, M; Martins, SO; Yamagami, H; Qiu, Z; Mansour, OY; Sathya, A; Czlonkowska, A; Tsivgoulis, G; Aguiar de Sousa, D

Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified ...


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