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Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation ...

Brandão, F; Costa, C; Bessa, MJ; Dumortier, E; Debacq-Chainiaux, F; Hubaux, R; Salmon, M; Laloy, J; Stan, MS; Hermenean, A; Gharbia, S; Dinischiotu, A

Several reports on amorphous silica nanomaterial (aSiO2 NM) toxicity have been questioning their safety. Herein, we investigated the in vivo pulmonary toxicity of four variants of aSiO2 NM: SiO2_15_Unmod, SiO2_15_Amino, SiO2_7 and SiO2_40. We focused on alterations in lung DNA and protein integrity, and gene expression following single intratracheal instillation in rats. Additionally, a short-term inhalation st...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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