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Recanalization after cerebral venous thrombosis : a randomized controlled trial...

Ferro, José; Bendszus, Martin; Jansen, Olav; Coutinho, Jonathan M; Dentali, Francesco; Kobayashi, Adam; de Sousa, Diana Aguiar; Lucas Neto, Lia

Background: The effect of different anticoagulants on recanalization after cerebral venous thrombosis has not been studied in a randomized controlled trial. Methods: RE-SPECT CVT (ClinicalTrials.gov number: NCT02913326) was a Phase III, prospective, randomized, parallel-group, open-label, multicenter, exploratory trial with blinded endpoint adjudication. Acute cerebral venous thrombosis patients were allocated ...


Safety and efficacy of Dabigatran Etexilate vs dose-adjusted Warfarin in patien...

Ferro, José; Coutinho, Jonathan M.; Dentali, Francesco; Kobayashi, Adam; Alasheev, Andrey; Canhão, Patrícia; Karpov, Denis; Nagel, Simon

Importance: Patients with cerebral venous thrombosis (CVT) are at risk of recurrent venous thrombotic events (VTEs). Non-vitamin K oral anticoagulants have not been evaluated in randomized controlled trials in CVT. Objective: To compare the efficacy and safety of dabigatran etexilate with those of dose-adjusted warfarin in preventing recurrent VTEs in patients who have experienced a CVT. Design, setting, and pa...


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