2 documents found, page 1 of 1
Synthesis and trypanocidal activity of ent-kaurane glycosides.
Batista, Ronan; Humberto, Jorge Luiz; Chiari, Egler; Oliveira, Alaíde Braga deNovel ent-kaurane glucosides were synthezised by a Koenigs–Knorr reaction between C17 and C19 alcohols derived from kaurenoic acid and 2,3,4,6-tetra-O-acetyl-glucopyranosyl bromide, followed by the hydrolysis of the acetates. Main products were assayed in vitro and in vivo against blood trypomastigote forms of Trypanosoma cruzi, the aetiological agent of Chagas’ disease (American trypanosomiasis). The results a...
Antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats.
Pádua, Bruno da Cruz; Silva, Lucas Dornela; Rossoni Júnior, Joamyr Victor; Humberto, Jorge Luiz; Chaves, Míriam Martins; Silva, Marcelo EustáquioEthnopharmacological relevance: Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as “carqueja”, it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. Aim of the study: The aim of the present study was to investigate the antioxidant ...