6 documents found, page 1 of 1
Exploring canine mast cell tumors : an investigation into demographic character...
Catarino, J.; Pinello, K.; Niza-Ribeiro, J.; Santos, J.; Payan-Carreira, R.; Reis, Joana; Faísca, P.Mast cell tumors (MCT) are among the most common neoplasia in dogs, representing up to 21 % of skin tumors. However, etiology and risk factors for its development remain unclear. This study aimed to reduce this knowledge gap by comprehensively analyzing 905 MCT cases diagnosed in Portugal between 2019 and 2021, using descriptive and inferential analyses. Most tumors affected the skin, with 69.9 % and 21.2 % cla...
Rational Approach to Design Gold Nanoparticles for Photothermal Therapy: the ef...
Ferreira-Gonçalves, T.; Nunes, D.; Fortunato, E.; Martins, R.; de Almeida, A.P.; Carvalho, L.; Ferreira, D.; Catarino, J.; Faísca, P.; Ferreira, H.A.Among the unique characteristics associated to gold nanoparticles (AuNPs) in biomedicine, their ability to convert light energy into heat opens ventures for improved cancer therapeutic options, such as photothermal therapy (PTT). PTT relies on the local hyperthermia of tumor cells upon irradiation with light beams, and the association of AuNPs with radiation within the near infrared (NIR) range constitutes an a...
Gold nanoparticles as a part of a photothermal therapy system.
Ferreira-Gonçalves, T.; Costa, E.; Coelho, J. M. P.; Gaspar, M. M.; Ascenção, L.; Faísca, P.; Figueiredo, I.V.; García-González, C.A.; Ferreira, D.Introduction Photothermal therapy (PTT) is attracting increased attention for the treatment of superficial localized tumors, relying on the induction of local hyperthermia of tumor cells upon their irradiation with light beams1. PTT efficacy depends, however, on the heat generated and, on the depth reached by the light. Some strategies to improve PTT efficacy includes the use of the near infrared (NIR, 650 to 9...
Animals in biomedical research : towards a more compassionate approach
Reis, J.; Oliveira, T.; Faísca, P.; Dantas, D.; Silva, S.; Frazão, O.The development of novel biosensors and other medical devices often implies extensive animal testing before the final phases of product development are reached. Most products do not reach the market. On the other hand, natural disease in companion animals often mirrors disease processes in humans, being a more accurate representation of the complexity of disease processes than laboratory animals. These are poor...
Evaluation of hematology, general serum biochemistry, bone turnover markers and...
Coelho, Catarina A.; Bordelo, João P.; Camassa, José A.; Barros, Vera A.; Babo, Pedro Miguel Sousa; Gomes, Manuela E.; Reis, R. L.; Azevedo, J. T.Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) application for 24 weeks and compared with a sham control group...
Development of TNBS-induced colitis: animal model to test new pharmacological a...
Mateus, V.; Faísca, P.; Mota-Filipe, H.; Sepodes, Bruno M.; Pinto, R.IBD is a gastro-intestinal disorder marked with chronic inflammation of intestinal epithelium, dam- aging mucosal tissue and manifests into several intestinal and extra-intestinal symptoms. Currently used medical therapy is able to induce and maintain the patient in remission, however no modifies or reverses the underlying pathogenic mechanism. The research of other medical approaches is crucial to the treatmen...