6 documents found, page 1 of 1
Plasma Metabolites Associated with OCT Features of Age-Related Macular Degenera...
Laíns, Inês; Han, Xikun; Gil, João; Providência, Joana; Nigalye, Archana; Alvarez, Rodrigo; Douglas, Vivian Paraskevi; Mendez, Kevin; Katz, RavivPurpose: The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better characterized by OCT. We and others have shown that patients with AMD have a distinct plasma metabolomic profile compared with controls. However, all studies to da...
Integrating genetics and metabolomics from multi-ethnic and multi-fluid data re...
Han, Xikun; Laíns, Inês; Li, Jun; Li, Jinglun; Chen, Yiheng; Yu, Bing; Qi, Qibin; Boerwinkle, Eric; Kaplan, Robert; Thyagarajan, BharatAge-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic genetic and metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16...
Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration
Laíns, Inês; Mendez, Kevin M; Gil, João Q.; Miller, John B; Kelly, Rachel S; Barreto, Patrícia Susana Correia Lopes; Kim, Ivana K; Vavvas, Demetrios GWe and others have shown that patients with different severity stages of age-related macular degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine is a biofluid that can be obtained non-invasively and, in other fields, urine metabolomics has been proposed as a feasible alternative to plasma biomarkers. However, no studies have applied urinary mass spectrometry (MS) metabolomic...
Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of...
Laíns, Inês; Chung, Wonil; Kelly, Rachel S.; Gil, João; Marques, Marco; Barreto, Patrícia; Murta, Joaquim N.; Kim, Ivana K.; Vavvas, Demetrios G.The pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness worldwide, remains only partially understood. This has led to the current lack of accessible and reliable biofluid biomarkers for diagnosis and prognosis, and absence of treatments for dry AMD. This study aimed to assess the plasma metabolomic profiles of AMD and its severity stages with the ultimate goal of contributing to...
Novel grid combined with peripheral distortion correction for ultra-widefield i...
Oellers, Patrick; Laíns, Inês; Mach, Steven; Garas, Shady; Kim, Ivana K; Vavvas, Demetrios G; Miller, Joan W; Husain, Deeba; Miller, John BPurpose: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ult...
Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retin...
Wang, Jay C.; Laíns, Inês; Providência, Joana; Armstrong, Grayson W.; B M Santos, Ana Rita; Gil, Pedro; Gil, João; Talcott, Katherine E.Purpose To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Setting: Multicenter. Patient Population: Total of 143 diabetic eyes—27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 w...