6 documents found, page 1 of 1
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Treatment of allergic rhinitis during and outside the pollen season using mobil...
Bédard, A.; Basagaña, X.; Anto, J. M.; Garcia-Aymerich, J.; Devillier, P.; Arnavielhe, S.; Bedbrook, A.; Onorato, G. L.; Czarlewski, W.; Murray, R.Background: The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information including the phenotypic characteristics of the users. Methods: The...
ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy"
Bosnic-Anticevich, S.; Costa, E.; Menditto, E.; Lourenço, O; Novellino, E.; Bialek, S.; Briedis, V.; Buonaiuto, R.; Chrystyn, H.; Cvetkovski, B.Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal ad...
Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld, C.; Ainsworth, H.; Cunninghame Graham, D.; Kelly, J.; Comeau, M.; Marion, M.; Howard, T.; Ramos, P.; Croker, J.; Morris, D.; Sandling, J.Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent association...
A new approach to the quantum modelling of biochemicals
Wallace, D.; Stoneham, A. M.; Testa, A.; Harker, A. H.; Ramos, Marta M. D.We describe a new approach to the quantum chemistry of biological molecules and other systems where complex geometry and bonding patterns cause problems. Our approach combines self-consistent quantum chemistry with molecular dynamics, removing the need to define interatomic potentials in advance. The method is illustrated using serotonin (both in free space and with model receptors) as an example.