7 documents found, page 1 of 1
Blood groups in Native Americans: a look beyond ABO and Rh
Rodrigues,Mirelen Moura de Oliveira; Höher,Gabriela; Waskow,Gabriela; Hutz,Mara Helena; Lindenau,Juliana Dal-Ri; Petzl-Erler,Maria LuizaAbstract The study presents comparisons between blood group frequencies beyond ABO and Rh blood systems in Native American populations and previously published data from Brazilian blood donors. The frequencies of Diego (c.2561C>T, rs2285644), Kell (c.578C>T, rs8176058), Duffy (c.125A>G, rs12075, c.1−67T>C, rs2814778) and Kidd (c.838A>G, rs1058396) variants in Kaingang (n=72) and Guarani (n=234) populations from...
Evaluation of Sexual Dimorphism in the Efficacy and Safety of Simvastatin/Atorv...
Smiderle,Lisiane; Lima,Luciana O.; Hutz,Mara Helena; Sand,Cézar Roberto Van der; Van der Sand,Luiz Carlos; Ferreira,Maria Elvira WagnerBackground: Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. Sex differences in the pharmacokinetics and pharmacodynamics of statins contribute to interindividual variations in drug efficacy and toxicity. Objective: To evaluate the presence of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin treatment. Method...
The Brazilian contribution to Attention-Deficit/Hyperactivity Disorder molecula...
Genro,Júlia Pasqualini; Roman,Tatiana; Rohde,Luis Augusto; Hutz,Mara HelenaAttention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric condition of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Diagnosis is based on a sufficient number of symptoms causing impairment in these two domains determining several problems in personal and academic life. Although genetic and environmental factors are importan...
Influência de combinações genéticas nos níveis de HDL-c em uma população do sul...
Andrade,Fabiana Michelsen de; Fiegenbaum,Marilu; Almeida,Silvana de; Hutz,Mara HelenaFUNDAMENTO: Baixos níveis de HDL-c são importantes preditores de doença coronariana, a primeira causa de morte no mundo todo. Muitos fatores afetam os níveis de HDL-c, tais como os polimorfismos de genes que codificam proteínas-chave para a via de transporte reverso de colesterol. OBJETIVO: Investigar a influência de sete polimorfismos dos genes CETP, APOA1, ABCA1 e SCARB1 genes nos níveis de HDL-c em uma popul...
A review of psychiatric genetics research in the Brazilian population
Cordeiro,Quirino; Souza,Bruno Rezende; Correa,Humberto; Guindalini,Camila; Hutz,Mara Helena; Vallada,Homero; Romano-Silva,Marco AurélioOBJECTIVE AND METHOD: A large increase in the number of Brazilian studies on psychiatric genetics has been observed in the 1970's since the first publications conducted by a group of researchers in Brazil. Here we reviewed the literature and evaluated the advantages and difficulties of psychiatric genetic studies in the Brazilian population. CONCLUSION: The Brazilian population is one of the most heterogeneous ...
(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
Kvitko,Kátia; Nunes,Janice Corrêa de Barros; Hutz,Mara HelenaWe investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.0...
Genetic diversity in a Brazilian bovine herd based on four microsatellite loci
Almeida,Sabrina E. Matos; Machado,Márcia S.N.; Steigleder,Clara Sabina; Gama,Cleonice L.; Hutz,Mara Helena; Henkes,Luiz Ernani; Moraes,José Carlos F.Microsatellites or short tandem repeats (STRs), DNA markers relatively abundant in the genome, have a high degree of polymorphism and therefore great potential for characterizing populations. The present study estimates genetic variability in a set of four microsatellites (BMS3013, BMS3004, HEL10 and TGLA122) in a Brazilian hybrid bovine breed (5/8 Aberdeen Angus x 3/8 Nelore). The objectives were to determine ...