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PLK4 is a microtubule-associated protein that self-assembles promoting de novo ...

Montenegro Gouveia, Susana; Zitouni, Sihem; Kong, Dong; Duarte, Paulo; Ferreira Gomes, Beatriz; Sousa, Ana Laura; Tranfield, Erin M.; Hyman, Anthony

The centrosome is an important microtubule-organising centre (MTOC) in animal cells. It consists of two barrel-shaped structures, the centrioles, surrounded by the pericentriolar material (PCM), which nucleates microtubules. Centrosomes can form close to an existing structure (canonical duplication) or de novo How centrosomes form de novo is not known. The master driver of centrosome biogenesis, PLK4, is critic...

Date: 2019   |   Origin: ARCA - Access to Research and Communication Annals
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PLK4 is a microtubule-associated protein that self assembles promoting de novo ...

Gouveia, Susana Montenegro; Zitouni, Sihem; Kong, Dong; Duarte, Paulo; Gomes, Beatriz Ferreira; Sousa, Ana Laura; Tranfield, Erin M.; Hyman, Anthony

The centrosome is an important microtubule-organizing centre (MTOC) in animal cells. It consists of two barrel-shaped structures, the centrioles, surrounded by the pericentriolar material (PCM), which nucleates microtubules. Centrosomes can form close to an existing structure (canonical duplication) or de novo How centrosomes form de novo is not known. The master driver of centrosome biogenesis, PLK4, is critic...

Date: 2018   |   Origin: ARCA - Access to Research and Communication Annals
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