3 documents found, page 1 of 1
Circulating small non-coding RNAs provide new insights into vitamin K nutrition...
I, Fernández; Fernandes, Jorge M. O.; Roberto, Vânia; Kopp, Martina; Oliveira, Catarina; Riesco, Marta F.; Dias, Jorge; Cox, Cymon J.Background: Vitamin K (VK) is a fat-soluble vitamin known for its essential role in blood coagulation, but also on other biological processes (e.g. reproduction, brain and bone development) have been recently suggested. Nevertheless, the molecular mechanisms behind its particular function on reproduction are not yet fully understood. Methods: The potential role of VK on reproduction through nutritional suppleme...
Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a do...
Granadeiro, Luis; Dirks, Ron P.; Ortiz-Delgado, Juan B.; J. Gavaia, Paulo; Sarasquete, Carmen; Laizé, Vincent; Leonor Cancela, M.; I, FernándezWarfarin is the most worldwide used anticoagulant drug and rodenticide. Since it crosses placental barrier it can induce warfarin embryopathy (WE), a fetal mortality in neonates characterized by skeletal deformities in addition to brain hemorrhages. Although the effects of warfarin exposure in aquatic off target species were already described, the particular molecular toxicological mechanisms during early devel...
The role of calcium concentration in the invasive capacity of Corbicula flumine...
Ferreira-Rodriguez, Noe; I, Fernández; Varandas, Simone; Cortes, Rui; Cancela, M. Leonor; Pardo, IsabelThe natural variation of environmental factors in freshwater basins determines their biodiversity. Among them, calcium is a key physiological compound for freshwater invertebrates. It is required for shell formation, muscle contraction, it mediates gene expression and allows counteracting acidosis during stress periods, among other functions. Although the distribution of different freshwater species has been su...