2 documents found, page 1 of 1
Each Cellular Compartment Has a Characteristic Protein Reactive Cysteine Ratio ...
Neves, Ricardo Pires das; Chagoyen, Mónica; Martinez-Lorente, Antonio; Iñiguez, Carlos; Calatrava, Ana; Calabuig, Juana; Iborra, Francisco JSignaling and detoxification of Reactive Oxygen Species (ROS) are important patho-physiologcal processes. Despite this, we lack comprehensive information on individual cells and cellular structures and functions affected by ROS, which is essential to build quantitative models of the effects of ROS. The thiol groups from cysteines (Cys) in proteins play a major role in redox defense, signaling, and protein funct...
Mitochondrial variability as a source of extrinsic cellular noise
Johnston, Iain G; Gaal, Bernadett; Neves, Ricardo Pires das; Enver, Tariq; Iborra, Francisco J; Jones, Nick SWe present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription, translation, stem cell differentiation and response to medication, but the specific random influences that affect these processes have yet to be clearly elucidated. Here we present a m...