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Half-sandwich Ru(p-cymene) compounds with diphosphanes: In Vitro and In Vivo ev...

Lenis Rojas, Oscar; Robalo, M. Paula; Tomaz, Ana Isabel; Fernandes, Alexandra; Roma-Rodrigues, Catarina; Gonçalves Teixeira, Ricardo; Marques, Fernanda

Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated as [Ru(p-cymene)(L)Cl]-[CF3SO3] (L = 1,1-bis(methylenediphenylphosphano)ethylene, 1; L = 1,1-bis(diphenylphosphano)ethylene, 2), which were characterized by elemental analysis, mass spectrometry, H-1...


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