2 documents found, page 1 of 1
Astrocyte progenitor transplantation promotes regeneration of bulbospinal respi...
Goulão, Miguel; Ghosh, Biswarup; Urban, Mark W.; Sahu, Malya; Mercogliano, Christina; Charsar, Brittany A.; Komaravolu, Sreeya; Block, Cole G.Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of r...
Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels...
Muqeem, Tanziyah; Ghosh, Biswarup; Pinto, Vítor Manuel Silva; Lepore, Angelo C.; Covarrubias, ManuelPresynaptic voltage-gated K+ (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. However, the Kv channel subtypes responsible for this critical role have not been identified. The Kv3.4 channel is particularly important because it is robustly expressed in DRG nociceptors, where it regulates action potential (AP) duration. Furthe...