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Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from t...
Rodrigues,Celso Arrais; Gonçalves,Matheus Vescovi; Ikoma,Maura Rosane Valério; Lorand-Metze,Irene; Pereira,André DominguesABSTRACT Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) es...
Proposal for the standardization of flow cytometry protocols to detect minimal r...
Ikoma,Maura Rosane Valério; Beltrame,Miriam Perlingeiro; Ferreira,Silvia Inês Alejandra Cordoba Pires; Souto,Elizabeth Xisto; Malvezzi,MariesterABSTRACT Minimal residual disease is the most powerful predictor of outcome in acute leukemia and is useful in therapeutic stratification for acute lymphoblastic leukemia protocols. Nowadays, the most reliable methods for studying minimal residual disease in acute lymphoblastic leukemia are multiparametric flow cytometry and polymerase chain reaction. Both provide similar results at a minimal residual disease lev...