72 documents found, page 1 of 8

Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular a...

A series of novel 9-alkyl/aryl-2-aryl-6-carbamoylpurines were synthesized, and their activity against $\text{Mycobacterium tuberculosis}$ strain $\text{H}37\text{Rv}$ was assessed. The $\text{SAR}$ analysis on the first set of derivatives, with an alkyl or aryl unit at $\text{N}$-$9$ and a phenolic unit at $\text{C}$-$2$, showed that the activity depends on the purine ring substituents at $\text{N}$-$9$ and $\t...

A vida no nosso planeta depende dos microrganismos

Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Comp...

Cellulose micro/nanomaterials (CMNM), comprising cellulose microfibrils (CMF), nanofibrils (CNF), and nanocrystals (CNC), are being recognized as promising bio-nanomaterials due to their natural and renewable source, attractive properties, and potential for applications with industrial and economical value. Thus, it is crucial to investigate their potential toxicity before starting their production at a larger ...

Purification and characterization of a thrombolytic enzyme produced by a new st...

Fibrinolytic enzymes with a direct mechanism of action and safer properties are currently requested for thrombolytic therapy. This paper reports on a new enzyme capable of degrading blood clots directly without impairing blood coagulation. This enzyme is also non-cytotoxic and constitutes an alternative to other thrombolytic enzymes known to cause undesired side effects. Twenty-four Bacillus isolates were scree...

Cytotoxicity Assessment of Novel Cellulose Nanomaterials on Intestinal Cells

Cellulose nanomaterials (CNMs) emerged as an important group of nanomaterials with potential applications in multiple food-related products, as zero-calorie filler/thickener/stabilizer, or as a substitute for petroleum-based food packaging materials. Human oral exposure to CNMs is increasing, but little is known about the potential adverse biological impact of CNMs on human gastrointestinal tract. To contribute...

Erratum for Oliveira et al., "K2 Capsule Depolymerase Is Highly Stable, Is Refr...

Volume 85, no. 17, e00934-19, 2019, https://doi.org/10.1128/AEM.00934-19. Page 10, Acknowledgments, lines 4 and 5: POCI-01-0145-FEDER-016678 should read POCI-01-0145-FEDER-016643.

Bacteriophage depolymerases: evolutionary insights and antivirulence strategies...

To be able to enter and replicate in exopolysaccharide slime or capsule surrounded bacteria, bacteriophages (viruses of bacteria) have evolved the ability to overcome the exopolysaccharides structure by producing virion-associated proteins with polysaccharide depolymerization activities. We have isolated > 20 bacteriophages infecting several species of the Acinetobacter baumannii-Acinetobacter calcoaceticus com...

Novel capsular depolymerases-based strategy to kill multidrug-resistant pathoge...

Multidrug resistant pathogens represent one of the greatest threats to human health of the new millennium. ESKAPE bacterial pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and other Enterobacteriaceae species) are the leading group among these socalled superbugs, which rapidly acquire resistances to several (and sometimes all) availa...

Increasing the potential of cell-penetrating peptides for cancer therapy using ...

Cancer treatment is one of the major fields of interest for the scientific community. Investment in cancer research is costly but essential to provide patients with more effective and safe treatments. In this project, we describe the synthesis and characterization of new thiazole derivatives coupled to CPP2, a cell-penetrating peptide (CPP) reported for colon cancer cells. Using a human adenocarcinoma-derived c...

Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ul...

Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects, negatively impact on patient adherence. In that sense, we tested the efficacy of an alternative strategy based on Lysin B (LysB), a phage encoded lipolytic enzyme...