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Generation of a genetically modified chimeric plasmodium falciparum parasite ex...

Miyazaki, Yukiko; Marin-Mogollon, Catherin; Imai, Takashi; Mendes, António M.; van der Laak, Rianne; Sturm, Angelika; Geurten, Fiona J. A.

Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) are used in preclinical evaluation of CSP vaccines. Chimeric rodent parasites expressing PfCSP have also been assessed as whole sporozoite (WSP) vaccines. Comparable chimeric P. falciparum parasites expressing CSP of P. vivax could be u...

Date: 2020   |   Origin: Repositório da Universidade de Lisboa
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