37 documents found, page 1 of 4

Assessing the impact of TiO2 nanomaterials on intestinal cells: New evidence fo...

Understanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...

Assessing the impact of TiO2 nanomaterials on intestinal cells

Understanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...

Efeitos da aflatoxina B1 na integridade e morfologia de células intestinais

Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...

About Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells

Overview of Adverse Outcome Pathways and Current Applications on Nanomaterials

Nanomaterials (NMs) have important and useful applications in chemical industry, electronics, pharmaceuticals, food and others. Their rapid proliferation presents a dilemma to regulators regarding hazard identification and increased concerns for public health. The Adverse Outcome Pathways (AOPs) are innovative central elements of a toxicological knowledge framework, developed for supporting chemical risk assess...

Oral Exposure to Titanium dioxide nanoparticles: a Systematic Literature Review...

Despite being considered key enabling technologies, the exponential use of nanoparticles in food technology leads to concerns about adverse health outcomes upon ingestion. The use of Titanium dioxide nanoparticles (TiO2-NPs) as a food additive was considered no longer safe by the European Food Safety Authority (EFSA) in 2022, and the European Commission announced the decision to ban its use. Nevertheless, other...

Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nano...

Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integr...

Investigation of the genotoxicity of digested titanium dioxide nanomaterials in...

The widespread use of titanium dioxide nanomaterials (TiO2 NMs) in food and consumer products such as toothpaste or food contact materials, suggests the relevance of human oral exposure to these nanomaterials (NMs) and raises the possibility of adverse effects in the gastrointestinal tract (GIT). We previously showed that the in vitro digestion of TiO2 NMs may increase their toxicity in intestinal cells. In thi...

Definition of an AOP landscape for ingested NMs

About definition of an Adverse Outcome Pathway landscape for ingested nanomaterials

Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomate...

Human exposure to titanium dioxide nanomaterials(TiO2NMs) occurs particularly by ingestion, due to food/food contact materials and consumer products. However, the possibility of adverse effects in gastrointestinal tract is unclear. Aiming to study the impact of digestion on the NMs’ properties and their cellular/molecular effects, two human intestinal cell lines were used, Caco-2 and HT29-MTX-E12. After exposur...