Funding Information: study, we conclude that the ADBR2 and CHRNA5 genes have a relevant role in the development of leiomyoma. This role appears to be enhanced by the epistatic relationship with the genes HTR2A and SLC6A4. This study, confirms the involvement of the Autonomous Nervous System in tumor biology, along with the genetics of the mechanisms, involved in chronic stress. By highlighting and helping to el...