4 documents found, page 1 of 1
Leiomyoma and the importance of genetic variation on genes related to the vascu...
Inácio, Angela; Aguiar, Laura; Rodrigues, Beatriz; Pires, Patrícia; Ferreira, Joana; Bilhim, Tiago; Pisco, João; Bicho, Manuel; Bicho, Maria ClaraObjective: The link between the systemic vasculature system and tumor biology is here investigated by studying the contribution of CβS (844ins68), MTHFR (677C > T), NOS3 (4a/4b), CYBA (C242T), and ACE1 (I/D) genes to leiomyoma onset, uterus and leiomyoma volumes. Methods: DNA samples from 130 women with leiomyomas and 527 from healthy women were genotyped by PCR or PCR-RFLP. Qui-square (χ2) or Fisher's exact te...
Genetic modulation of HPV infection and cervical lesions: role of oxidative str...
Inácio, Angela; Aguiar, Laura; Rodrigues, Beatriz; Pires, Patrícia; Ferreira, Joana; Matos, Andreia; Mendonça, Inês; Rosa, Raquel; Bicho, ManuelHuman papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-relate...
Interaction between HFE and haptoglobin polymorphisms and its relation with pla...
Aguiar, Laura; Marinho, Cláudia; Martins, Rute; Alho, Irina; Ferreira, Joana; Levy, Pilar Quinhones; Faustino, Paula; Bicho, Manuel; Inácio, AngelaObesity among children has emerged as a serious public health problem. The growing prevalence of childhood obesity has led to the appearance of serious complications, including a chronic systemic inflammation associated with oxidative stress. In the present study, we analysed the interaction between two genes related with iron metabolism - HFE and haptoglobin - and the plasmatic concentration of glutathione, as...
Global analysis of the small RNA transcriptome in different ploidies and genomi...
Inácio, Angela; Pinho, Joana; Pereira, Patrícia Matos; Comai, Luca; Coelho, Maria ManuelaThe Squalius alburnoides complex (Steindachner) is one of the most intricate hybrid polyploid systems known in vertebrates. In this complex, the constant switch of the genome composition in consecutive generations, very frequently involving a change on the ploidy level, promotes repetitive situations of potential genomic shock. Previously in this complex, it was showed that in response to the increase in genome...