4 documents found, page 1 of 1
Creation and Validation of the European Portuguese Version of the Systemic Lupu...
Ferreira, Pedro Lopes; Cunha, Rita Novais; Macieira, Carla; Fontes, Tomás; Inês, Luís; Maduro, Ana Isabel Ramos; Martins, Ana; Rajão, Frederico(1) Background: Patients with systemic lupus erythematous (SLE) experience profound effects on health-related quality of life (HRQoL) that cannot be explained by objective indicators of mortality and morbidity. This study aimed to adapt the SLE Quality of Life (SLEQoL) questionnaire to the European Portuguese population and to assess its reliability and validity for patients with SLE. (2) Methods: Two independe...
Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Sys...
Henriques, Ana; Inês, Luís; Couto, Maura; Pedreiro, Susana; Santos, Catarina; Magalhães, Mariana; Santos, Paulo; Velada, Isabel; Almeida, AnabelaTo compare frequency and functional activity of peripheral blood (PB) Th(c)17, Th(c)1 and Treg cells and the amount of type 2 cytokines mRNA we recruited SLE patients in active (n = 15) and inactive disease (n = 19) and healthy age- and gender-matched controls (n = 15). The study of Th(c)17, Th(c)1 and Treg cells was done by flow cytometry and cytokine mRNA by real-time PCR. Compared to NC, SLE patients present...
Sera from patients with active systemic lupus erythematosus patients enhance th...
Carvalheiro, Tiago; Gomes, Diane; Pinto, Ligia A; Inês, Luís; Lopes, Ana; Henriques, Ana; Pedreiro, Susana; Martinho, António; Trindade, HélderBackground: Systemic Lupus Erythematosus (SLE) is an auto-immune disease whose complex pathogenesis remains unraveled. Here we aim to explore the inflammatory ability of SLE patients’ sera upon peripheral blood (PB) monocyte subsets and myeloid dendritic cells (mDCs) obtained from healthy donors. Methods: In this study we included 11 SLE patients with active disease (ASLE), 11 with inactive disease (ISLE) and 1...
Tolerogenic versus inflammatory activity of peripheral blood monocytes and dend...
Carvalheiro, Tiago; Rodrigues, Ana; Lopes, Ana; Inês, Luís; Velada, Isabel; Ribeiro, Andreia; Martinho, António; Silva, José A. P.; Pais, Maria L.Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA expression, respectively, after cell purification. The study included 18 SLE patients with active disease (ASLE), 25 with inactive disease (ISLE), and 30 healthy c...