4 documents found, page 1 of 1
Desenvolvimento de um sensor ótico biomimético para a deteção da proteína CA19-9
Xu, AnaA doença oncológica, nas últimas décadas, tem demonstrado uma tendência crescente, tornando-se num problema de saúde pública. Um dos pontos principais para um melhor prognóstico consiste na deteção precoce do cancro, contudo quando estes são assintomáticos, como o cancro do pâncreas, a deteção, muitas vezes, é tardia, deixando passar uma oportunidade para tratamento que seria importante. Esta deteção tardia tra...
Optical immunosensor panel using quantum dot-antibody conjugates for highly sen...
Oliveira, Daniela; Oliveira, Pedro; Xu, Ana; Rodrigues, Eduarda; Guerreiro, Susana G.; Castro, Rafael C.; Ribeiro, David S. M.; Santos, João L. M.This study introduces a fluorescent immunosensor colour panel with antibody-conjugated quantum dots for detecting CA19-9 in human serum. The immunosensors presented decreasing fluorescence with increasing CA19-9 concentrations, with a linear detection range from 0.01 to 501.87 U mL−1 and detection limits of 1.66 × 10⁻⁴, 2.71 × 10⁻⁴, and 5.45 × 10⁻⁴ U mL−1 for the green-, orange-, and red-emitting conjugates in ...
Detection of CA19-9 using fluorescent polymer imprinted membranes
Xu, Ana; Piloto, Ana Margarida L.(Introduction) The Carbohydrate antigen19-9 (CA19-9) is a biomarker widely used for the diagnosis and monitoring of various types of cancer, especially pancreatic cancer (PC). Molecularly Imprinted Polymers (MIPs) are synthetic materials with recognition sites molecularly designed to bind selectively to a target analyte, providing high specificity and sensitivity. In this work, the use of solid supports such as...
Optical detection of CA19-9 protein using yellow quantum dots with molecularly ...
Xu, Ana; Piloto, Ana Margarida L.(Introduction) Biosensors are crucial for rapid and accurate diagnoses, vital for effective treatment strategies. ❖ Traditional immunoassays have susceptibility to instability and compromise the accuracy of the results. Molecularly imprinted polymers (MIP) are emerging as biomimetic sensors that offer stability, selectivity, and resistance to environmental variations. Quantum dots (QDs) have versatile optical d...