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Treating sickle cell disease in resource-limited sub-Saharan Africa: recent str...

Brito, Miguel; Ginete, Catarina; Ofakunrin, Akinyemi; Diaku-Akinwumi, Ijeoma; Inusa, Baba Psalm

Introduction: The management of Sickle cell disease (SCD) in sub-Saharan Africa (SSA) suffers from the lack of universal infant and population screening, inadequate access to standard treatment, and poor public health prioritization amidst unstable political systems. Areas covered: The state of evidence-based management of SCD in SSA was investigated, including the sustainability of international funding agenci...


An update review of new therapies in sickle cell disease: the prospects for dru...

Lugthart, Sanne; Ginete, Catarina; Kuona, Patience; Brito, Miguel; Inusa, Baba Psalm

Introduction: Sickle cell disease (SCD) is an inherited disorder characterized by polymerization of deoxygenated hemoglobin and microvascular obstruction. Generalized, it affects millions of people over 85% from low-and-middle-income countries. The cardinal feature is generalized pain referred to as vaso-occlusive crises (VOC), multi-organ damage, and premature death.). SCD is the most prevalent inherited reduc...


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