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Monosodium glutamate neonatal treatment induces cardiovascular autonomic functi...

Konrad, Signorá Peres; Farah, Vera; Rodrigues, Bruno; Wichi, Rogério Brandão; Machado, Ubiratan Fabres; Lopes, Heno Ferreira; Schaan, Beatriz D'Agord

OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressur...

Date: 2012   |   Origin: Oasisbr


Short-term diabetes attenuates left ventricular dysfunction and mortality rates...

Rodrigues, Bruno; Figueroa, Diego Mendrot Taboas; Fang, Jiao; Rosa, Kaleizu Teodoro; Llesuy, Suzana; De Angelis, Kátia; Irigoyen, Maria Cláudia

OBJECTIVES: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. INTRODUCTION: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. METHODS: Male Wistar rats were divid...

Date: 2011   |   Origin: Oasisbr

Sildenafil preserves diastolic relaxation after reduction by L-NAME and increas...

Ferreira-Melo, Silvia Elaine; Demacq, Caroline; Lacchini, Silvia; Krieger, José Eduardo; Irigoyen, Maria Cláudia; Moreno, Heitor

OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treated with L-NAME and/or sildenafil for eight weeks. The Langendorff method was used to examine the effects of sildena...

Date: 2011   |   Origin: Oasisbr

Simvastatin-induced cardiac autonomic control improvement in fructose-fed femal...

Silva, Renata Juliana da; Bernardes, Nathalia; Brito, Janaina de O.; Sanches, Iris Callado; Irigoyen, Maria Cláudia; Angelis, Kátia De

OBJECTIVE: Because autonomic dysfunction has been found to lead to cardiometabolic disorders and because studies have reported that simvastatin treatment has neuroprotective effects, the objective of the present study was to investigate the effects of simvastatin treatment on cardiovascular and autonomic changes in fructose-fed female rats. METHODS: Female Wistar rats were divided into three groups: controls (n...

Date: 2011   |   Origin: Oasisbr

Effect of resistance and aerobic exercise on the autonomic control and hemodyna...

Cal Abad, César Cavinato; Silva, Ricardo Severino da; Mostarda, Cristiano; Silva, Ivana Cinthya de Moraes da; Irigoyen, Maria Cláudia

A prática de exercícios aeróbicos e resistidos provoca ajustes agudos e crônicos distintos. Já foram documentadas diferenças hemodinâmicas e musculares entre os exercícios; todavia, quanto aos ajustes autonômicos, os estudos são escassos e controversos. O objetivo deste estudo foi analisar as adaptações hemodinâmicas e autonômicas após uma sessão de exercício aeróbico (30 minutos, bicicleta ergométrica) e resis...

Date: 2010   |   Origin: Oasisbr

Insulin therapy does not interfere with venous endothelial function evaluation ...

Silva, Antônio Marcos Vargas da; Penno, Luciana de Moraes; Bertoluci, Marcello Casaccia; Irigoyen, Maria Cláudia; Schaan, Beatriz D'Agord

INTRODUCTION: Endothelium-dependent dilation is improved in insulin-treated diabetic patients, but this effect is probably due to improved glycemic control. The objective of the present study was to compare endothelium-dependent dilation in patients with well-controlled type 2 diabetes who are or are not using insulin as part of their therapy. METHODS: We studied 27 patients with type 2 diabetes (11 women, 60.3...

Date: 2010   |   Origin: Oasisbr

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