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Usefulness of Routine Fractional Flow Reserve for Clinical Management of Corona...

Van Belle, E; Cosenza, A; Bravo Baptista, S; Vincent, F; Henderson, J; Santos, L; Ramos, R; Pouillot, C; Calé, R; Cuisset, T; Jorge, E; Teiger, E

Importance: Approximately one-third of patients considered for coronary revascularization have diabetes, which is a major determinant of clinical outcomes, often influencing the choice of the revascularization strategy. The usefulness of fractional flow reserve (FFR) to guide treatment in this population is understudied and has been questioned. Objective: To evaluate the usefulness and rate of major adverse car...


Inferences on specificity recognition at the Malus×domestica gametophytic self-...

Pratas, M; Aguiar, B; Vieira, J; Nunes, V; Teixeira, V; Fonseca, N; Iezzoni, A; Van Nocker, S; Vieira, CP

In Malus × domestica (Rosaceae) the product of each SFBB gene (the pollen component of the gametophytic self-incompatibility (GSI) system) of a S-haplotype (the combination of pistil and pollen genes that are linked) interacts with a sub-set of non-self S-RNases (the pistil component), but not with the self S-RNase. To understand how the Malus GSI system works, we identified 24 SFBB genes expressed in anthers, ...



Impact of Routine Fractional Flow Reserve on Management Decision and 1-Year Cli...

Van Belle, E; Bravo Baptista, S; Raposo, L; Henderson, J; Rioufol, G; Santos, L; Pouillot, C; Ramos, R; Cuisset, T; Calé, R; Teiger, E; Jorge, E

Background: Fractional flow reserve (FFR) is not firmly established as a guide to treatment in patients with acute coronary syndromes (ACS). Primary goals were to evaluate the impact of integrating FFR on management decisions and on clinical outcome of patients with ACS undergoing coronary angiography, as compared with patients with stable coronary artery disease. Methods and results: R3F (French FFR Registry) ...


Impact of Routine Fractional Flow Reserve Evaluation During Coronary Angiograph...

Baptista, SB; Raposo, L; Santos, L; Ramos, R; Calé, R; Jorge, E; Machado, C; Costa, M; Oliveira, E; Costa, J; Pipa, J; Fonseca, N; Guardado, J; Silva, B

Penetration of fractional flow reserve (FFR) in clinical practice varies extensively, and the applicability of results from randomized trials is understudied. We describe the extent to which the information gained from routine FFR affects patient management strategy and clinical outcome. METHODS AND RESULTS: Nonselected patients undergoing coronary angiography, in which at least 1 lesion was interrogated by FFR...


Schimke immuno-osseous dysplasia: case report and review of 25 patients

Saraiva, JM; Dinis, A; Resende, C; Faria, E; Gomes, C; Correia, AJ; Gil, J; Fonseca, N

Immuno-osseous dysplasia is characterised by spondyloepiphyseal dysplasia, lymphopenia with defective cellular immunity, and progressive renal disease. We describe a patient with a severe form of the disease, review the features of another 24 patients, and discuss the previous classification. The differences between the two groups are not striking, and although similarities are greater between affected sibs, th...


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