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Contextual Hospital Conditions and the Risk of Nosocomial SARS-CoV-2 Infection:...

Almeida, F; Correia, S; Leal, C; Guedes, M; Duro, R; Andrade, P; Pedrosa, A; Rocha-Pereira, N; Lima-Alves, C; Azevedo, A

Objective: Knowledge of the role of hospital conditions in SARS-CoV-2 transmission should inform strategies for the prevention of nosocomial spread of this pathogen and of similarly transmitted viruses. This study aimed to identify risk factors for nosocomial acquisition of SARS-CoV-2. Methods: We ran a nested case-control study with incidence density sampling among adult patients hospitalized for >7 days (Augu...


Appropriateness of Empirical Prescriptions of Ceftriaxone and Identification of...

Gorgulho, A; Cunha, F; Branco, EA; Azevedo, A; Almeida, F; Duro, R; Andrade, P; Pereira, NR; Alves, CL

Third-generation cephalosporins are widely used due to the convenient spectrum of activity, safety, and posology. However, they are associated with the emergence of multidrug-resistant organisms, which makes them important targets for antimicrobial stewardship interventions. We aimed to assess the appropriateness of empirical prescriptions of ceftriaxone in a tertiary hospital. This cross-sectional study analys...


Validation of a semi-automated surveillance system for surgical site infections...

Malheiro, R; Rocha-Pereira, N; Duro, R; Pereira, C; Alves, CL; Correia, S

Objectives. To assess whether electronic records data could improve the efficiency, exhaustiveness, and representativeness of SSI surveillance by selecting a group of high-risk patients for manual review. Methods. Colorectal surgeries (2016–2018) and cholecystectomies (2017–2018) were selected. Post-surgical antibiotic use, positive culture, C-reactive protein (CRP) values, body temperature, leukocyte count, su...


Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case S...

Prista-Leão, B; Abreu, I; Duro, R; Silva-Pinto, A; Ceia, F; Andrade, P; Sobrinho-Simões, J; Tavares, M; Pereira, JM; Santos, L; Sarmento, A

Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our cen...


Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovir...

Palma, P; Costa, A; Duro, R; Neves, N; Abreu, C; Sarmento, A

BACKGROUND: Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and ...


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