2 documents found, page 1 of 1
MiR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 a...
Fuentes-Mattei, E; Bayraktar, R; Manshouri, T; Silva, AM; Ivan, C; Gulei, D; Fabris, L; Amaral, NS; Mur, P; Perez, C; Torres-Claudio, E; Dragomir, MPMyelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAKV617F mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to JAK2V617F inhibitor therapy remains unknown. Among MF patients who...
Profiling the circulating miRnome reveals a temporal regulation of the bone inj...
Silva, AM; Almeida, MI; Teixeira, JH; Ivan, C; Oliveira, J; Vasconcelos, DM; Neves, N; Ribeiro-Machado, C; Cunha, C; Barbosa, MA; Calin, G; Santos, SGBone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the ...