7 documents found, page 1 of 1
Hybridization in the Anthropocene – how pollution and climate change disrupt ma...
Ramirez‐Duarte, Wilson F.; Moran, Benjamin M.; Powell, Daniel L.; Bank, Claudia; Sousa, Vitor C; Rosenthal, Gil G.; Schumer, Molly; Rochman, Chelsea M.Chemical pollutants and/or climate change have the potential to break down reproductive barriers between species and facilitate hybridization. Hybrid zones may arise in response to environmental gradients and secondary contact between formerly allopatric populations, or due to the introduction of non-native species. In freshwater ecosystems, field observations indicate that changes in water quality and chemistr...
In search of the Goldilocks zone for hybrid speciation II: hard times for hybri...
Blanckaert, Alexandre; Sriram, Vedanth; Bank, ClaudiaHybridization opens a unique window for observing speciation mechanisms and is a potential engine of speciation. One controversially discussed outcome of hybridization is homoploid hybrid speciation by reciprocal sorting, where a hybrid population maintains a mixed combination of the parental genetic incompatibilities, preventing further gene exchange between the newly formed population and the two parental sou...
The Adaptive Potential of the Middle Domain of Yeast Hsp90
Cote-Hammarlof, Pamela, A.; De mendonça fragata almeida, Inês; Flynn, Julia; Mavor, David; Zeldovich, Konstantin; Bank, Claudia; Bolon, Daniel N.A.The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given environment and its cost in others. So far, results regarding the cost of adaptation across environments have been mixed, and most studies have sampled random mutations across different genes. Here, we quantify systematically how costs of adaptation vary along a large stre...
The fitness landscape of the codon space across environments
Fragata, Inês; Matuszewski, Sebastian; Schmitz, Mark A.; Bataillon, Thomas; Jensen, Jeffrey D.; Bank, ClaudiaFitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitness effects of synonymous mutations and their potential impact on adaptation on a fitness landscape, we use a new software based on Bayesian Monte Carlo Markov ...
In search of the Goldilocks zone for hybrid speciation
Blanckaert, Alexandre; Bank, ClaudiaHybridization has recently gained considerable interest both as a unique opportunity for observing speciation mechanisms and as a potential engine for speciation. The latter remains a controversial topic. It was recently hypothesized that the reciprocal sorting of genetic incompatibilities from parental species could result in hybrid speciation, when the hybrid population maintains a mixed combination of the pa...
Conflict between heterozygote advantage and hybrid incompatibility in haplodipl...
Ghenu, Ana-Hermina; Blanckaert, Alexandre; Butlin, Roger K.; Kulmuni, Jonna; Bank, ClaudiaIn many diploid species the sex chromosomes play a special role in mediating reproductive isolation. In haplodiploids, where females are diploid and males haploid, the whole genome behaves similarly to the X/Z chromosomes of diploids. Therefore, haplodiploid systems can serve as a model for the role of sex chromosomes in speciation and hybridization. A previously described population of Finnish Formica wood ant...
The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution
Ormond, Louise; Liu, Ping; Matuszewski, Sebastian; Renzette, Nicholas; Bank, Claudia; Zeldovich, Konstantin; Bolon, Daniel N.; Kowalik, Timothy F.Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mutation rate of influenza A virus (IAV). Potential synergistic benefits of combining oseltamivir and favipiravir have been demonstrated in animal models of inf...