Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million people worldwide, and chronic production of the cytokines IFN-γ and TNF-α by T cells together with mitochondrial dysfunction are important players for the poor prognosis of the disease. Mitochondria occupy 40% of the cardiomyocytes volume a...
Made available in DSpace on 2019-10-04T12:37:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-24; Brazilian National Research Council; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Peptides represent a large class of cell signaling molecules, and they are mainly produced by the classical secretory pathway or during protein degradation. The peptide profile of Danio rerio (zebrafish) ...