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Neuroprotection by BDNF against glutamate-induced apoptotic cell death is media...
Almeida, R. D.; Manadas, B. J.; Melo, C. V.; Gomes, J. R.; Mendes, C. S.; Grãos, M. M.; Carvalho, R. F.; Carvalho, A. P.; Duarte, C. B.Neurotrophins protect neurons against glutamate excitotoxicity, but the signaling mechanisms have not been fully elucidated. We studied the role of the phosphatidylinositol 3-kinase (PI3-K) and Ras/mitogen-activated protein kinase (MAPK) pathways in the protection of cultured hippocampal neurons from glutamate induced apoptotic cell death, characterized by nuclear condensation and activation of caspase-3-like e...
Date: 2005
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Origin: Estudo Geral - Universidade de Coimbra