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Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase
Sousa,Lorena R. F. de; Ramalho,Suelem D.; Fernandes,João B.; Silva,Maria Fátima das G. F. da; Iemma,Mônica R. da C.; Corrêa,Caroindes J.Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the ...
Data: 2014
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Origem: Oasisbr