6 documents found, page 1 of 1
Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5
Jacinto, Raquel; Sampaio, Pedro; Roxo-Rosa, Mónica; Pestana, Sara; Lopes, Susana S.Funding: This work was supported by the Fundação para a Ciência e a Tecnologia (FCT-ANR/BEX-BID/0153/2012 research grant). SL is funded by an FCT CEEC contract for Principal Investigator. The work was also supported by Sociedade Portuguesa de Nefrologia (research grant 2015), iNOVA4Health – UID/Multi/04462/2013 (a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ci...
Zebrafish model as a screen to prevent cyst inflation in autosomal dominant pol...
Oliveira, Inês; Jacinto, Raquel; Pestana, Sara; Nolasco, Fernando; Calado, Joaquim; Lopes, Susana Santos; Roxo-Rosa, MónicaFunding Information: Funding: This work was supported by Sociedade Portuguesa de Nefrologia, iNOVA4Health-UID/Multi/04462/2013 (a program financially supported by Fundação para a Ciência e Tecnolo-gia (FCT)/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement) and FCT-ANR/BEX-BID/0153/2012 and PTDC/BEX-BID/1411/2014 research grants. M.R.R. was su...
Rab35 controls cilium length, function and membrane composition
Kuhns, Stefanie; Seixas, Cecília; Pestana, Sara; Tavares, Bárbara; Nogueira, Renata; Jacinto, Raquel; Ramalho, José S.; Simpson, Jeremy C.8021-00425B) to JSA, by a postdoctoral fellowship from FCT (SFRH/BPD/32323/2006) to CS and by iNOVA4Health—UID/Multi/ 04462/2013, a program financially supported by FCT/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement. This article is supported by the LYSOCIL project. This project has received funding from the European Union’s Horizon 2020 re...
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
Burkhalter, Martin D.; Sridhar, Arthi; Sampaio, Pedro; Jacinto, Raquel; Burczyk, Martina S.; Donow, Cornelia; Angenendt, Max; Hempel, MajaAbout 1% of all newborns are affected by congenital heart disease (CHD). Recent findings identify aberrantly functioning cilia as a possible source for CHD. Faulty cilia also prevent the development of proper left-right asymmetry and cause heterotaxy, the incorrect placement of visceral organs. Intriguingly, signaling cascades such as mTor that influence mitochondrial biogenesis also affect ciliogenesis, and ca...
Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Fox...
Tavares, Barbara; Jacinto, Raquel; Sampaio, Pedro; Pestana, Sara; Pinto, Andreia; Vaz, Andreia; Roxo-Rosa, Mónica; Gardner, Rui; Lopes, Telmaundacao para a Ciencia e a Tecnologia PTDC/BEX-BID/1411/2014 Susana Santos Lopes Fundacao para a Ciencia e a Tecnologia FCT-ANR/BEX-BID/0153/2012 Sara Pestana Fundacao para a Ciencia e a Tecnologia PTDC/SAU-OBD/103981/2008 Andreia Vaz Fundacao para a Ciencia e a Tecnologia PD/BD/52420/2013 Raquel Jacinto Fundacao para a Ciencia e a Tecnologia SFRH/BPD/77258/2011 Barbara Tavares Fundacao para a Ciencia e a Tecno...
The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms ...
Roxo-Rosa, Mónica; Jacinto, Raquel; Sampaio, Pedro; Lopes, Susana SantosWork supported by Fundacao para a Ciencia e a Tecnologia [FCT-ANR/BEX-BID/0153/2012 research grant], including funding for M.R.-R. and P.S. S.S.L. has a FCT-Investigator contract and R.J. a PhD fellowship [PD/BD/52420/2013].; In autosomal dominant polycystic kidney disease (ADPKD), cyst inflation and continuous enlargement are associated with marked transepithelial ion and fluid secretion into the cyst lumen vi...