47 documents found, page 1 of 5
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo ...
Domingues, Neuza; Gaifem, Joana; Matthiesen, Rune; Saraiva, Diana P.; Bento, Luís; Marques, André R.A.; Soares, Maria I.L.; Sampaio, JulioFunding Information: supported by FCT through projects UIDB/00313/2020 and UIDP/00313/2020. Funding Information: R. S. group has been funded by national funds, through the FCT—project numbers UIDB/50026/2020 and UIDP/ 50026/2020 and 2020.00185. CEECIND to the FCT. Funding Information: N. D. was a holder of a PhD fellowship from the FCT (Ref. N◦: SFRH/BD/51877/2012). Funding Information: The authors acknowledge ...
theLiTE™
Gomes, Teresa Lopes; Oliveira-Marques, Virgínia de; Hampson, Richard John; Jacinto, Antonio; de Moraes, Luciana Vieira; Martinho, Rui Gonçalo745175.; Tight junctions (TJ) are formed by transmembrane and intracellular proteins that seal the intercellular space and control selective permeability of epithelia. Integrity of the epithelial barrier is central to tissue homeostasis and barrier dysfunction has been linked to many pathological conditions. TJ support the maintenance of cell polarity through interactions with the Par complex (Cdc42-Par-6-Par-3...
A regeneration-triggered metabolic adaptation is necessary for cell identity tr...
Brandão, Ana S.; Borbinha, Jorge; Pereira, Telmo; Brito, Patrícia H.; Lourenço, Raquel; Bensimon-Brito, Anabela; Jacinto, AntonioFunding Funder Grant reference number Author Fundação para a Ciência e a Tecnologia PTDC/BIA-BID/29709/2017 Ana S Brandão Fundação para a Ciência e a Tecnologia PTDC/BTMSAL/29377/2017 Ana S Brandão Fundação para a Ciência e a Tecnologia UIDB/04462/2020 Ana S Brandão Fundação para a Ciência e a Tecnologia LA/P/0087/2020 Ana S Brandão Fundação para a Ciência e a Tecnologia LISBOA-01-0145- FEDER-022170 Ana S Brand...
Circulating low density neutrophils of breast cancer patients are associated wi...
Saraiva, Diana P; Correia, Bruna F; Salvador, Rute; de Sousa, Nídia; Jacinto, Antonio; Braga, Sofia; Cabral, MGFunding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).; Neutrophils are prominent immune components of tumors, having either anti-tumor (N1) or pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low densi...
Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas
Lourenço, Raquel; Brandão, Ana S.; Borbinha, Jorge; Gorgulho, Rita; Jacinto, AntonioFunding: This work was supported by funding from Fundação para a Ciência e Tecnologia, in the context of a program contract to RL (4, 5, and 6 of article 23.◦ of D.L. no. 57/2016 of August 29, as amended by Law no. 57/2017 of 19 July), UIDB/04462/2020 and PTDC/BIM-MED/0659/2014 in the context of a grant project; SFRH/BPD/93453/2013 to RL, SFRH/BD/51990/2012 to AB, SFRH/BD/131929/2017 to JB, and SFRH/BD/140124/2...
The right time for senescence
De-Carvalho, Diogo Paramos; Jacinto, Antonio; Saúde, LeonorFunding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).; Cellular senescence is ...
A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Di...
Silva, Nuno Valério; Carregosa, Diogo; Gonçalves, Catarina; Vieira, Otília V.; Nunes dos Santos, Cláudia; Jacinto, Antonio; Crespo, Carolina LageFunding: This work was funded by the Fundação para a Ciência e a Tecnologia (FCT; PTDC/BTM-SAL/29377/2017 to CC and AJ. Zebrafish were reproduced and maintained by the CEDOC Fish Facility, supported by Congento LISBOA-01-0145- FEDER-022170, co-financed by FCT (Portugal) and Lisboa2020, under the PORTUGAL2020 agreement (European Regional Development Fund).; Inflammatory bowel diseases (IBD) with chronic infiltra...
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida; Dias, Ana Filipa; Neves-Silva, Dalila; Pereira, Telmo; Chapela, DianaFunding Information: We are grateful to A. Nascimento, A. Temudo, and J. Rino from the Bioimaging Unit for all of their precious advice. We thank the support given by the Fish and Rodent Facilities and the Histology and Comparative Pathology Laboratory, A. Ribeiro and C. de Sena-Tomás for critical reading of the manuscript, and M. Rebocho-da-Costa for help with the graphical abstract. D.P.d.C. was supported by ...
Expression of hla-dr in cytotoxic t lymphocytes
Saraiva, Diana P.; Azeredo-Lopes, Sofia; Antunes, Ana; Salvador, Rute; Borralho, Paula; Assis, Beatriz; Pereira, Isabel L.; Seabra, Zita; Negreiros, IdaFunding Information: Funding: This work was supported by Terry Fox Research Grant 2019 from Liga Portuguesa Contra o Cancro; Clinical Research Prize 2018 from Consortium Tagus Tank; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015 for DPS and SFRH/BD/148422/2019 for RS) and iNOVA4Health (UIDB/04462/2020, DAI/2019/46). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.; Neoadju...
The right time for senescence
Paramos-de-Carvalho, Diogo; Jacinto, Antonio; Saúde, LeonorCellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue r...