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Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR...
Veloso Júnior, Paulo Henrique de Holanda; Simon, Karina Smidt; Castro, Raffael Júnio Araújo de; Coelho, Luísa Coutinho; Hurtado Erazo, Fabián AndresAntimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated with peptides plus LP...
Venom gland transcriptome analyses of two freshwater stingrays (Myliobatiformes...
Oliveira Júnior, Nelson Gomes de; Fernandes, Gabriel da Rocha; Cardoso, Marlon Henrique; Costa, Fabricio Falconi; Cândido, Elizabete de SouzaStingrays commonly cause human envenoming related accidents in populations of the sea, near rivers and lakes. Transcriptomic profiles have been used to elucidate components of animal venom, since they are capable of providing molecular information on the biology of the animal and could have biomedical applications. In this study, we elucidated the transcriptomic profile of the venom glands from two different fr...
Bowman-Birk protease inhibitor from Vigna unguiculata seeds enhances the action...
Álvares, Alice da Cunha Morales; Schwartz, Elisabeth Nogueira Ferroni; Amaral, Nathalia Oda; Trindade, Neidiane Rosa; Pedrino, Gustavo RodriguesThe hydrolysis of bradykinin (Bk) by different classes of proteases in plasma and tissues leads to a decrease in its half-life. Here, Bk actions on smooth muscle and in vivo cardiovascular assays in association with a protease inhibitor, Black eyed-pea trypsin and chymotrypsin inhibitor (BTCI) and also under the effect of trypsin and chymotrypsin were evaluated. Two synthetic Bk-related peptides, Bk1 and Bk2, w...
Activity of scorpion venom-derived antifungal peptides against planktonic cells...
Guilhelmelli, Fernanda; Vilela, Nathália; Smidt, Karina S.; Oliveira, Marco Antônio de; Álvares, Alice da Cunha MoralesThe incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and acquired resistance of some fungal species to available therapies, associated with the high toxicity of these drugs on the present scenario and makes an imperative of the search for new, more efficient and less toxic therapeutic choices. Antimicrobial pep...
Non-disulfide-Bridge peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits t...
Trentini, Monalisa Martins; Neves, Rogério Coutinho das; Santos, Bruno de Paula Oliveira; Silva, Roosevelt Alves da; Souza, Adolfo CarlosMulti-drug resistant microorganisms have been a growing concern during the last decades due to their contribution in mortality rates worldwide. Antimicrobial peptides (AMPs) are broad spectrum antimicrobial agents that display potent microbicidal activity against a wide range of microorganisms. AMPs generally have a rapid mode of action that reduces the risk of resistance developing among pathogens. In this stu...
Protease inhibitors from marine venomous animals and their counterparts in terr...
Mourão, Caroline Barbosa Farias; Schwartz, Elisabeth Nogueira FerroniThe Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms. These inhibitors consist of a chain of ~60 amino acid residues stabilized by three disulfide bridges, and was first observed in the bovine pancreatic trypsin inhibitor (BPTI)-like protease inhibitors, which strongly inhibit trypsin and chymotrypsin. In this r...
Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscuru...
Guerrero Vargas, Jimmy Alexander; Mourão, Caroline Barbosa Farias; Quintero Hernández, Verónica; Possani, Lourival D.Background: Colombia and Brazil are affected by severe cases of scorpionism. In Colombia the most dangerous accidents are caused by Tityus pachyurus that is widely distributed around this country. In the Brazilian Amazonian region scorpion stings are a common event caused by Tityus obscurus. The main objective of this work was to perform the molecular cloning of the putative Na+-channel scorpion toxins (NaScTxs...
Antiviral activity of animal venom peptides and related compounds
Mata, Élida Cleyse Gomes da Mata; Mourão, Caroline Barbosa Farias; Rangel, Marisa; Schwartz, Elisabeth Nogueira FerroniViruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases...
Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gert...
Schwartz, Elisabeth Nogueira Ferroni; Garcia, Elia Diego; Rodríguez de la Vega, Ricardo C.; Possani, Lourival D.Background: Scorpions like other venomous animals posses a highly specialized organ that produces, secretes and disposes the venom components. In these animals, the last postabdominal segment, named telson, contains a pair of venomous glands connected to the stinger. The isolation of numerous scorpion toxins, along with cDNA-based gene cloning and, more recently, proteomic analyses have provided us with a large...
Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscuru...
Guerrero Vargas, Jimmy Alexander; Mourão, Caroline Barbosa Farias; Quintero Hernández, Verónica; Possani, Lourival D.Background: Colombia and Brazil are affected by severe cases of scorpionism. In Colombia the most dangerous accidents are caused by Tityus pachyurus that is widely distributed around this country. In the Brazilian Amazonian region scorpion stings are a common event caused by Tityus obscurus. The main objective of this work was to perform the molecular cloning of the putative Na+-channel scorpion toxins (NaScTxs...