2 documents found, page 1 of 1
Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld, C.; Ainsworth, H.; Cunninghame Graham, D.; Kelly, J.; Comeau, M.; Marion, M.; Howard, T.; Ramos, P.; Croker, J.; Morris, D.; Sandling, J.Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent association...
Evaluation of intermolecular interactions in thioxanthone derivatives: substitu...
Jacob, C.; da Piedade, Fátima M.; Paula Robalo, M.; Teresa Duarte, M.A family of 9H-thioxanthen-9-one derivatives and two precursors, 2-[(4-bromophenyl) sulfanyl]-5-nitrobenzoic acid and 2-[(4-aminophenyl) sulfanyl]-5-nitrobenzoic acid, were synthesized and studied in order to assess the role of the different substituent groups in determining the supramolecular motifs. From our results we can conclude that Etter's rules are obeyed: whenever present the -COOH head to head strong ...