4 documents found, page 1 of 1
Cystic fibrosis and amyotrophic lateral sclerosis, an unexpected association
Jacob, M; Cardoso, CG; Redondo, M; Gonçalves, MR; Pinto, M; Amorim, A
The effect of alcohol consumption in the treatment of nontuberculous mycobacteria
Jacob, M; Silva, R; Gaio, R; Duarte, RNontuberculous mycobacteria (NTM) are considered opportunistic pathogens. They are widely distributed in the environment, and several species are associated with a wide range of infections, most commonly affecting the lung. The increasing number of immunocompromised patients and predisposing diseases – such as chronic obstructive pulmonary disease (COPD), silicosis and bronchiectasis—as well as the increasing l...
Hypersensitivity pneumonitis: Main features characterization in a Portuguese co...
Santos, V; Martins, N; Sousa, C; Jacob, M; Padrão, E; Melo, N; Mota, PC; Bastos, HN; Guimarães, S; Moura, CS; Sokhatska, O; Cunha, R; Pereira, JHypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a c...
Targeted gene next-generation sequencing panel in patients with advanced lung a...
Fernandes, MGO; Jacob, M; Martins, N; Moura, CS; Guimarães, S; Reis, J; Justino, A; Pina, MJ; Cirnes, L; Sousa, C; Pinto, J; Marques, JA; Machado, JCIdentification of targetable molecular changes is essential for selecting appropriate treatment in patients with advanced lung adenocarcinoma. Methods: In this study, a Sanger sequencing plus Fluorescence In Situ Hybridization (FISH) sequential approach was compared with a Next-Generation Sequencing (NGS)-based approach for the detection of actionable genomic mutations in an experimental cohort (EC) of 117 pati...