4 documents found, page 1 of 1
Effects of Quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal ...
Effects of quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle Cell anemia (SCA) is a hereditary hemoglobinopathy with the formation of hemoglobin S, associated with severe health outcomes. Currently, induction of fetal hemoglobin (HbF) is one of the most promising therapeutic strategies. Here we aimed to assess the potential of the natural compound Quercetin, in transcriptional expression of globin and HbF regulatory/silencing genes. In this study, the K562 cell li...
Effects of methanolic and aqueous Carica Papaya leaf extracts in transcriptiona...
Jacques, Filipa; Delgadinho, Mariana; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Introduction: Hemoglobinopathies are genetic blood disorders characterized by abnormal hemoglobin that disrupts oxygen transport and leads to diverse health complications. Raising fetal hemoglobin (HbF) levels is one possible therapeutic approach. But the current main therapy based on the use of hydroxyurea (HU), faces limitations related to cost and safety, especially in underserved areas. To overcome these co...
Effects of methanolic and aqueous Carica Papaya leaf extracts in transcriptiona...
Jacques, Filipa; Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle cell disease (SCD) is a genetic blood disorder caused by mutations in β-globin gene that affect the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of Fetal Hemoglobin (HbF) through compounds such as Hydroxyurea (HU), is one of the available treatments, however, their safety concerns and expensive cost in low- and middle...