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Maternal hemoglobin and iron status in early pregnancy and childhood cardiac ou...

Quezada-Pinedo, HG; Jaddoe, V; Gaillard, R; Duijts, L; van Rijn, B; Reiss, IKM; Vermeulen, MJ; Santos, S

Background & aims: Dysregulation of iron homeostasis is associated with cardiac alterations in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy has long-term impact on cardiovascular health, and if this association is influenced by sex. Therefore, this study aimed to evaluate sex-specific association between maternal iron status during early pregnancy and cardiac outcomes in ...


Maternal iron status in early pregnancy and childhood body fat measures and car...

Quezada-Pinedo, HG; Jaddoe, V; Duijts, L; Muka, T; Vermeulen, MJ; Reiss, IKM; Santos, S

Background Whether maternal iron status during pregnancy is associated with cardiometabolic health in the offspring is poorly known. Objectives We aimed to assess the associations of maternal iron status during early pregnancy with body fat measures and cardiometabolic risk factors in children aged 10 y. Methods In a population-based cohort study among 3718 mother–child pairs, we measured ferritin, transferrin,...


Impact of maternal body mass index and gestational weight gain on pregnancy com...

Santos, S; Voerman, E; Amiano, P; Barros, H; Beilin, LJ; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costa, O

Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gai...


Fish intake during pregnancy, fetal growth, and gestational length in 19 Europe...

Leventakou, V; Roumeliotaki, T; Martinez, D; Barros, H; Brantsaeter, AL; Casas, M; Charles, MA; Cordier, S; Eggesbo, M; van Eijsden, M; Forastiere, F

BACKGROUND: Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants. OBJECTIVE: We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies. DESIGN: The study sample of 151,880 mother-child pairs was derived from 19 popula...


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