18 documents found, page 1 of 2
A meta-analysis of epigenome-wide association studies of ultra-processed food c...
Llauradó-Pont, J; Stratakis, N; Fiorito, G; Handakas, E; Neumann, A; Barros, H; Brantsæter, AL; Chang, K; Chatzi, L; Felix, JF; Grazuleviciene, R"Background/objective: There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered. We therefore aimed to assess the association between UPF consumption and DNA methylation in children. Methods: We conducted a meta-analysis of epigenome-wide association studies (EWAS) fro...
Fetal exposure to phthalates and body mass index from infancy to adolescence. T...
Sol, CM; Delgado, G; Kannan, K; Jaddoe, VWV; Trasande, L; Santos, SPrenatal exposure to phthalates might influence the development of childhood obesity. Most previous studies used body mass index (BMI) at a specific age instead of BMI development, which might be a better indicator of later health. We aimed to assess the association of prenatal phthalate exposure with longitudinal BMI development from infancy to adolescence. Among 1,379 mother-child pairs from a population-base...
Longitudinal associations of air pollution and green space with cardiometabolic...
Liu, M; Vaartjes, I; Hoek, G; Jaddoe, VWV; Santos, S; Schreuder, A; Vrijkotte, TGM; Grobbee, DE; Timmermans, EJBackground: This study examines longitudinal associations of air pollution and green space with cardiometabolic risk among children in the Netherlands. Methods: Three Dutch prospective cohorts with a total of 13,822 participants aged 5 to 17 years were included: (1) the Amsterdam Born Children and their Development (ABCD) study from Amsterdam (n = 2,547), (2) the Generation R study from Rotterdam (n = 5,431), a...
Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes:...
Fernandes, A; Avraam, D; Cadman, T; Dadvand, P; Guxens, M; Binter, A-C; Pinot de Moira, A; Nieuwenhuijsen, M; Duijts, L; Julvez, J; De Castro, MStudies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European bi...
Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Ea...
Gonçalves Soares, A; Santos, S; Seyve, E; Nedelec, R; Puhakka, S; Eloranta, A-M; Mikkonen, S; Yuan, WL; Lawlor, DA; Heron, J; Vrijheid, M; Lepeule, JBackground: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (S...
Body composition and respiratory outcomes in children: a population-based prosp...
Wu, T; Santos, S; Quezada-Pinedo, HG; Vernooij, MW; Jaddoe, VWV; Klein, S; Duijts, L; Oei, EHGBackgroundBody composition might influence lung function and asthma in children, but its longitudinal relations are unclear. We aimed to identify critical periods for body composition changes during childhood and adolescence in relation to respiratory outcomes in adolescents.MethodsIn a population-based prospective cohort study, we measured body mass index, fat mass index (FMI), lean mass index (LMI) and the ra...
Risk factors and cardio-metabolic outcomes associated with metabolic-associated...
de Groot, J; Santos, S; Geurtsen, ML; Felix, JF; Jaddoe, VWVBackground Non-Alcoholic Fatty Liver Disease (NAFLD) is defined as increased liver fat percentage, and is the most common chronic liver disease in children. Rather than NAFLD, Metabolic-Associated Fatty Liver Disease (MAFLD), defined as increased liver fat with presence of adverse cardio-metabolic measures, might have more clinical relevance in children. We assessed the prevalence, risk-factors and cardio-metab...
Long-term cardiometabolic health in people born after assisted reproductive tec...
Elhakeem, A; Taylor, AE; Inskip, HM; Huang, JY; Mansell, T; Rodrigues, C; Asta, F; Blaauwendraad, SM; Haberg, SE; Halliday, J; Harskamp-van Ginkel, MWAims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 popu...
Gestational age at birth and body size from infancy through adolescence: An ind...
Vinther, JL; Cadman, T; Avraam, D; Ekstrom, CT; Sorensen, TIA; Elhakeem, A; Santos, AC; de Moira, AP; Heude, B; Iñiguez, C; Pizzi, C; Simons, EBackground Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. ...
Associations of green and blue space exposure in pregnancy with epigenetic gest...
Marques, I; Santos, S; Monasso, GS; Fossati, S; Vrijheid, M; Nieuwenhuijsen, M; Jaddoe, VWV; Felix, JFEarly life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these associations. In 1359 mother-newborn pairs from the population-based Generation R Study, we examined the associati...