6 documents found, page 1 of 1
Genetic determinants of fungi-induced ROS production are associated with the ri...
Matzaraki, Vasiliki; Beno, Alexandra; Jaeger, Martin; Gresnigt, Mark S.; Keur, Nick; Boahen, Collins; Cunha, Cristina; Gonçalves, Samuel M.; Leite, LuisReactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated f...
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
Gresnigt, Mark S.; Cunha, Cristina; Jaeger, Martin; Gonçalves, Samuel Martins; Malireddi, R. K. Subbarao; Ammerdorffer, Anne; Lubbers, RosalieInvasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with ...
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity...
Stappers, Mark H.T.; Clark, Alexandra E.; Aimanianda, Vishukumar; Bidula, Stefan; Reid, Delyth M.; Asamaphan, Patawee; Hardison, Sarah E.Resistance to infection is critically dependent on the ability of pattern recognition receptors to recognize microbial invasion and induce protective immune responses. One such family of receptors are the C-type lectins, which are central to antifungal immunity. These receptors activate key effector mechanisms upon recognition of conserved fungal cell-wall carbohydrates. However, several other immunologically a...
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity...
Stappers, Mark H. T.; Clark, Alexandra E.; Aimanianda, Vishukumar; Bidula, Stefan; Reid, Delyth M.; Asamaphan, Patawee; Hardison, Sarah E.Resistance to infection is critically dependent on the ability of pattern recognition receptors to recognize microbial invasion and induce protective immune responses. One such family of receptors are the C-type lectins, which are central to antifungal immunity. These receptors activate key effector mechanisms upon recognition of conserved fungal cell-wall carbohydrates. However, several other immunologically a...
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
Gresnigt, Mark S.; Cunha, Cristina; Jaeger, Martin; Gonçalves, Samuel M.; Malireddi, R. K. Subbarao; Ammerdorffer, Anne; Lubbers, RosalieInvasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with ...
The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulatio...
Gresnigt, Mark S.; Jaeger, Martin; Malireddi, R. K. Subbarao; Rasid, Orhan; Jouvion, Gregory; Fitting, Catherine; Melchers, Willem J. G.One of the major life-threatening infections for which severely immunocompromised patients are at risk is invasive aspergillosis (IA). Despite the current treatment options, the increasing antifungal resistance and poor outcome highlight the need for novel therapeutic strategies to improve outcome of patients with IA. In the current study, we investigated whether and how the intracellular pattern recognition re...