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Analysis of Stereotyped B-Cell Receptor Frequencies Among Portuguese De Novo-Di...

Alves, Daniela; Ferreira, Gisela; Caldas, Joana; Fernandes, Mariana; Gaspar, Cátia; Alpoim, Mafalda; Carvalhais, Inês; Duarte, Sara; Silva, Helena

Background/objectives: Chronic lymphocytic leukemia (CLL) exhibits a heterogeneous clinical course influenced by genetic factors, such as the mutational status of immunoglobulin variable regions (IGHV). Recently, B-cell receptor (BcR) stereotypes have shown promising prognostic value, potentially surpassing IGHV status. The PAIS study analyzed BcR stereotypes and IGHV mutations in newly diagnosed Portuguese CLL...

Date: 2025   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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