14 documents found, page 1 of 2
Desenvolvimento e validação de um método para análise morfométrica e fractal da...
Jamacaru, Francisco Vagnaldo FechineTumor growth is dependent on the induction of angiogenesis, a complex pathophysiological process that can be modified by the action of drugs. Thus, the development of methods that appropriately quantify tumor angiogenesis, both in human tumors and in experimental cancer models, is imperative for the evaluation of the therapeutic efficacy of antiangiogenic drugs. Therefore, the objective of this study was to dev...
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a ...
Braga, Vanessa Nogueira Lages; Juanes, Camila de Carvalho; Peres Júnior, Hélio de Souza; Sousa, José Robson de; Cavalcanti, Bruno CoêlhoPurpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p.). The follow up along 16 weeks ...
Impact of testicular sperm extraction and testicular sperm aspiration on gonada...
Barroso, Leocácio Venícius Sousa; Reges, Ricardo; Cerqueira, João Batista Gadelha; Miranda, Eduardo P.; Alcantara, Rafael Jorge Alves dePurpose: To assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared. Materials and Methods: A pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 rats, wh...
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a ...
Braga, Vanessa Nogueira Lages; Juanes, Camila de Carvalho; Peres Júnior, Hélio de Souza; Sousa, José Robson de; Cavalcanti, Bruno CoêlhoPurpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p.). The follow up along 16 weeks ...
PanCD44 immunohistochemical evaluation in Prostatectomies from patients with ad...
Hirth, Carlos Gustavo; Santos, Adriele Machado dos; Cerqueira, João Batista Gadelha de; Jamacaru, Francisco Vagnaldo FechineIntroduction. CD44 has been proposed as a prognostic marker and a stem cell marker but studies in patients with prostate cancer have yielded inconsistent results. Patients and Methods. Patients submitted to radical prostatectomy between 2008 and 2013 at a university hospital were followed with biannual serum PSA tests to determine the biochemical recurrence (BR). Archived paraffin blocks with neoplastic and non...
Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge impl...
Melo, Nayanna de Oliveira Ramos; Juanes, Camila de Carvalho; Alves, Mayara Freire de Alencar; Silva, Emiliano Tiago MeloPurpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg...
Transitional metaplasia in intestinal epithelium of rats submitted to intestina...
Santos, Alessandra Marques dos; Coelho, Joao Paulo Ferreira; Juanes, Camila de Carvalho; Azevedo, Rafael Barbosa de; Diniz, Clara AraujoPurpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks. Resu...
Estudo de toxicologia clínica de um fitoterápico contendo Passiflora incarnata ...
Nascimento, Demétrius F.; Santana, Ana Paula M.; Leite, Ismenia O.; Viana, Fernando André C.; Leite, Ana Lourdes A. e Silva; Moraes, Renata A. de“Clinical toxicology study of an herbal medicine with Passiflora incarnata L., Crataegus oxyacantha L., Salix alba L. in healthy volunteers”. Pasalix® is an herbal medicine containing a combination of three medicinal plants: Passiflora incarnata, Salix alba and Crataegus oxyacantha . Its main indication is to treat anxiety and insomnia. The purpose of this study was to evaluate the clinical toxicology of that f...
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of therma...
Campelo, Ana Paula Bomfim Soares; Campelo, Márcio Wilker Soares; Brito, Gerly Anne de Castro; Jamacaru, Francisco Vagnaldo FechinePURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. METHODS: Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 ...
Effects of chronic administration of tamsulosin and tadalafil, alone or in comb...
Regadas, Rommel Prata; Reges, Ricardo; Cerqueira, João Batista Gadelha; Sucupira, Daniel Gabrielle; Jamacaru, Francisco Vagnaldo FechinePurpose: The aim of this study was to define if tadalafil causes detrusor muscle impairment and to observe the effect of combination of tadalafil with tamsulosin on the lower urinary tract of rats with bladder outlet obstruction (BOO) induced by chronic nitric oxide deficiency. Materials and Methods: Thirty-one male rats were randomized to following groups: 1 - control; 2 - L-Nitroarginine methyl ester (L-NAME)...