3 documents found, page 1 of 1
Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis
Rama, TA; Henriques, AF; Matito, A; Jara-Acevedo, M; Caldas, C; Mayado, A; Muñoz-González, JI; Moreira, A; Cavaleiro Rufo, J; García-Montero, ABackground Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown. Objective To investigate the potential association between ...
Mast Cell Activation Syndromes: Comparison Between Two Scoring Models to Predic...
Rama, TA; Torrado, I; Henriques, AF; Sánchez-Muñoz, L; Jara-Acevedo, M; Navarro-Navarro, P; Caldas, C; Mayado, A; Muñoz-González, J; García-Montero, ABACKGROUND: The Red Espanola de Mastocitosis (Spanish Network on Mastocytosis) score (REMAs) and the National Institutes of Health idiopathic clonal anaphylaxis score (NICAS) were developed for more efficient screening of mast cell (MC) clonality in MC activation syndromes. In a limited idiopathic anaphylaxis case series, the NICAS showed higher accuracy compared with the REMAs. OBJECTIVE: To compare the perfor...
Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorder...
Bárcena, P; Jara-Acevedo, M; Tabernero, MD; López, A; Sánchez, ML; García-Montero, AC; Muñoz-García, N; Vidriales, MB; Paiva, A; Lecrevisse, Q; Lima, MCurrently, the lack of a universal and specific marker of clonality hampers the diagnosis and classification of chronic expansions of natural killer (NK) cells. Here we investigated the utility of flow cytometric detection of aberrant/altered NK-cell phenotypes as a surrogate marker for clonality, in the diagnostic work-up of chronic lymphoproliferative disorders of NK cells (CLPD-NK). For this purpose, a large...