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Children and youth participation in digital environment: a systematic literatur...
Costa, Conceição; Pereira, Sara; Brandão, Daniel; Pinto, Diana; Jardim, CarolinaIn the digital environment, as well in their offline lives, children and youth have the right to freedom of expression as well the right of participation. Research on children’s participation and voice in the media is expanding, although the objectives and the actual actions of their participation is less studied. In this study, using conceptualisations of children and youth1 media participation as social inter...
Sustained macrophage reprogramming is required for CD8+ T cell–dependent long-t...
Jardim, Carolina; Bica, Marta; Reis-Sobreiro, Mariana; Mota, Afonso Teixeira da; Lopes, Raquel; Ferreira-Pinto, Miguel Alexandre; Sousa, Neuza S.Tumor-associated macrophages (TAM) exhibit a dual role in tumor progression and antitumor immunity. However, understanding the functional states and molecular mechanisms of antitumor TAMs remains a challenge. Herein, we show that intratumoral administration of a combination of agonists against TLR3 and CD40 [hereafter termed myeloid cell treatment (MCT)] reprogrammed TAMs in situ to adopt a protective antitumor...
Vivências digitais de crianças e jovens em Portugal: Um estudo qualitativo sobr...
Pereira, Sara; Jardim, Carolina; Pessôa, Clarisse Alves MonteiroEstudos nacionais e internacionais têm mostrado que as redes sociais têm vindo a assumir um papel central nas práticas mediáticas, em particular das novas gerações. Crianças e jovens usam cada vez mais estas plataformas, formando os seus repertórios de acordo com os papéis e os significados que atribuem a cada rede. Este artigo pretende analisar os usos das redes sociais por crianças e jovens portugueses com id...
Formas de participação de jovens com origem migrante em associações em Portugal
Jardim, Carolina; Silva, Sofia Marques daA participação cívica de jovens com origem imigrante é uma área de estudo que carece de atenção académica em Portugal. Este artigo pretende analisar as várias formas de envolvimento e participação de jovens afrodescendentes, e de origem ucraniana e romena em associações de imigrantes em Portugal. O trabalho empírico centrou-se num conjunto de nove associações de imigrantes. Através de um estudo de caso múltiplo...
Formas de participação de jovens com origem migrante em associações em Portugal
Jardim, Carolina; Silva, Sofia Marques daA participação cívica de jovens com origem imigrante é uma área de estudo que carece de atenção académica em Portugal. Este artigo pretende analisar as várias formas de envolvimento e participação de jovens afrodescendentes, e de origem ucraniana e romena em associações de imigrantes em Portugal. O trabalho empírico centrou-se num conjunto de nove associações de imigrantes. Através de um estudo de caso múltiplo...
Bringing macrophages to the frontline against cancer: current Immunotherapies t...
Reis-Sobreiro, Mariana; Teixeira da Mota, Afonso; Jardim, Carolina; Serre, KarineMacrophages are found in all tissues and display outstanding functional diversity. From embryo to birth and throughout adult life, they play critical roles in development, homeostasis, tissue repair, immunity, and, importantly, in the control of cancer growth. In this review, we will briefly detail the multi-functional, protumoral, and antitumoral roles of macrophages in the tumor microenvironment. Our objectiv...
Questioning the proverb ‘more haste, less speed’: classic versus metabarcoding ...
Gil, Vanessa; Pinho, Catarina J.; Aguiar, Carlos A.S.; Jardim, Carolina; Sampaio e rebelo, Rui; Vasconcelos, RaquelDietary studies can reveal valuable information on how species exploit their habitats and are of particular importance for insular endemics conservation as these species present higher risk of extinction. Reptiles are often neglected in island systems, principally the ones inhabiting remote areas, therefore little is known on their ecological networks. The Selvagens gecko Tarentola (boettgeri) bischoffi, endemi...
Identification and microbial production of the raspberry phenol salidroside tha...
Kallscheuer, Nicolai; Menezes, Regina; Foito, Alexandre; Henriques da Silva, Marcelo D.; Braga, Adelaide; Dekker, Wijbrand; Sevillano, David MéndezEdible berries are considered to be among nature's treasure chests as they contain a large number of (poly)phenols with potentially health-promoting properties. However, as berries contain complex (poly)phenol mixtures, it is challenging to associate any interesting pharmacological activity with a single compound. Thus, identification of pharmacologically interesting phenols requires systematic analyses of berr...
BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits
Dudnik, Alexey; Almeida, A. Filipa; Andrade, Ricardo; Avila, Barbara; Bañados, Pilar; Barbay, Diane; Bassard, Jean-Etienne; Benkoulouche, MounirBACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using ba...
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulati...
Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; Tomás-Barberán, Francisco A.Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary (poly)phenols revert and prevent age-related cognitive decline and neurodegeneration in model systems. However, only l...