2 documents found, page 1 of 1
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A re...
Freitas, Renata Nascimento de; Kay-Tee, Khaw; Wu, Kelvin; Bowman, Richard; Jeffery, Hannah; Luben, Robert; Wareham, Nick J.; Bingham, Sheila A.The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available....
A HMGCR polymorphism is associated with relations between blood pressure and ur...
Freitas, Renata Nascimento de; Khaw, Kay-Tee; Wu, Kelvin; Bowman, Richard; Jeffery, Hannah; Luben, Robert; Wareham, Nick J.; Bingham, Sheila A.A polymorphism in the HMGCR gene (rs17238540) was related to a lower response to pravastatin treatment and we aimed to investigate whether an interaction is present for this polymorphism on blood pressure (BP) and salt intake. Cross-sectional urinary sodium and potassium concentration and the polymorphism were assessed in a large population study. Participants with the mutated allele (G) had significantly highe...